This meme humorously contrasts the operational styles of the American Mafia and the Sicilian Mafia (Cosa Nostra). It highlights the American Mafia’s tendency to work in shadows and avoid harming police or politicians due to fear of persecution, juxtaposed against the Sicilian Mafia’s reputation for overt violence and aggression, represented by the character from Aqua Teen Hunger Force saying “Oh boy, here I go killing again.”