The joke is partly that lots of trans women in particular enjoyed this game in particular, so plenty of people who noticed the switcheroo in the tweet will still see it as an opportunity to talk about the game rather than seeing the game as something irrelevant that could be swapped out for another.
It’s pretty plausible that Epstein would be suicidal after being locked up and would have killed himself if left unattended in his own jail cell with some rope, especially as giving him some rope would signal that he wasn’t going to get saved. The more sensible conspiracy theory is that he was taken off suicide watch intentionally to give him the opportunity.