So many nice recommendations here but here are some of my recommendations in genres (in top 5 form). All of them have PC ports (but not all of the series may be available on PC)

Platformers:

1. Rayman
2. Sonic
3. Wonder boy
4. Shantae
5. Trine

RPGs

1. Final Fantasy
2. Tales of Series
3. Star Ocean
4. Elder Scrolls
5. Pathfinder

Some noteworthy mentions for RPGs

1. YS
2. Mana

Shooters:

1. Medal of Honor
2. Shadow Warrior
3. Doom
4. Call of Duty
5. Wolfenstein

Puzzles, point and click: Note: This was very hard to list since most of them are standalone and those that are not have interesting plot lines that you will not appreciate unless you play in order such as Syberia, Gabriel Knight, Secret Files. Walking Dead)

1. Myst (You can play in any order but it would be nice to play the sequels or prequels)
2. Broken Sword (Don’t touch 4 and 5 but you can play in any order and it would be nice to play the sequels or prequels)
3. Life is Strange (1 and 2 are standalone stories)
4. of Loathing series (It has turned based combat but very fun)
5. Nancy Drew

I would say I prefer them in the chronological order of their release date. Some of the series I have listed completely have either loosely, small references or completely standalone only sharing a “franchise name”