I have no experience with PCSX2, but maybe something in its configuration causes your issues. Reinstalling or updating it will not make a difference. If you really want to start over, close the application, remove the directory ~/.config/PCSX2 and restart the application. You will have to run through the initial wizard again. If it still won’t work, some other issue is the culprit and you would likely need to share logs. Alternatively, if the application prints logging to stdout, you could run the application from a terminal (f.e. by launching pcsx2-qt) and see if anything is printed there when it shuts down.