My home server is running OMV (which is really just Debian with a web GUI), and all the services (outside of SMB/Wireguard) are running in Docker containers. I used to like to tinker, but as my server got more mature, I just wanted it to work. If OMV went away tomorrow, I would pivot to Debian because of its stability.

Laptop/desktop are running Pop_OS! Like the relative stability, but the frequent updating of the kernel for hardware support.

Are you running KDE or Gnome? If you’re using Gnome, there’s an extension to manage wireguard. I flip a switch in the top bar, and done.